Chapter 1 About

e-Campsis is a desktop application developed by Calvagone that provides an intuitive and user-friendly interface for setting up population PK/PD simulations.

The app runs on the localhost in the user’s web browser (e.g. Edge or Chrome) and invokes the users own R environment to execute simulations with the help of a series of open-source packages like campsis, campsismod, campsisnca (see here for details campsis. These packages use rxode2 or mrgsolve as simulation engine per the users choice.

1.1 e-Campsis versions

e-Campsis standard includes the following additional functionality:

  • Save/load e-Campsis projects
  • NONMEM®, Monolix® and rxode2 code import
  • Number of arms, scenarios, subjects, observations only limited by memory
  • Advanced customization of plots
  • NCA & summary statistics
  • Overlay external data on plots
  • Bootstrap covariates from external file or NHANES
  • Personalized support via email

Advanced features such as an AI assistant to facilitate the setup of simulations and a qualification suite are available in an advanced version. Please check the full feature list here: e-Campsis

For further information, contact us at the following e-mail address:

1.2 Application interface

The app consists of 7 main sections:

  • Model: a powerful model editor to edit your Campsis model online. Try out one of the numerous models available from the library and adapt it to your needs.
  • Trial design: an easy-to-use interface to quickly set-up the dosing regimen, observation times and covariates.
  • Simulation: a single screen dedicated to the simulation configuration and visualization of the results. Explore different scenarios of parameter settings quickly and interactively. Overlay external data and produce beautiful ggplot2-based plots.
  • Post-processing: here you can define summary variables such as non-compartmental PK parameters that you want to derive from your simulation results and show them in a table.
  • R-code: the R script configuration section provides instructions explaining that all actions performed in the interface can be exported as an R script using the open-source Campsis ecosystem.
  • Settings: define R server configuration of the user interface.
  • Info: displays license information, application version, and contact details for support.

Additionally, under the File menu, you can open, save, or create e‑Campsis projects, or open a new tab. The Examples menu provides ready-to-use projects.